Whey and whey isolate comparison
Optimum Nutrition Gold Standard 100% Isolate vs Dymatize ISO100 Hydrolyzed
ON Gold Standard Isolate scores higher on our standard, 71/100 to 63/100. It earns more points for protein density (81% vs 78% protein by weight). We could not verify a current price for Dymatize ISO100, so we can't compare cost.
Both are scored out of 100 against our published standard: protein density, third-party testing, label transparency, sugar, ingredient simplicity and verified label data. Every number below is from the manufacturer's label; last checked 2026-10-13.
Optimum Nutrition
Gold Standard 100% Isolate
Side by side
Per serving, from each label. Bold marks the better score, protein density, sugar and cost where the two differ. How we score
| Compared | ON Gold Standard Isolate | Dymatize ISO100 |
|---|---|---|
| Our score | 71/100 (better) | 63/100 |
| Protein density | 30 / 30 (better)81% of each scoop is protein | 22 / 3078% of each scoop is protein |
| Third-party testing | 0 / 25No verified independent testing program | 0 / 25No verified independent testing program |
| Label transparency | 20 / 20Fully disclosed formula, no amino spiking | 20 / 20Fully disclosed formula, no amino spiking |
| Sugar | 10 / 100 g sugar per serving | 10 / 101 g sugar per serving |
| Ingredient simplicity | 6 / 10Mix of natural and artificial flavors or sweeteners | 6 / 10Mix of natural and artificial flavors or sweeteners |
| Verified label data | 5 / 57 of 7 label values verified | 5 / 57 of 7 label values verified |
| Type | Whey Isolate | Whey Isolate |
| Protein per serving | 25 g | 25 g |
| Serving size | About 1 Scoop (31g) | 1 scoop (32g) |
| Protein by weight | 81% (better) | 78% |
| Sugar | 0 g (better) | 1 g |
| Calories | 110 | 120 |
| Cost per 25 g protein | $2.35 | Not verified |
| Price per serving | $2.35 | Not verified |
| Third-party certifications | None found | None found |
| Sweeteners | Sucralose | Sucralose, Steviol Glycosides |
| Allergens | Milk, Soy | Milk, Soy |
| Proprietary blend | No | No |
| Added free amino acids (amino spiking) | No | No |
| Last checked | 2026-10-13 | 2026-10-13 |
Which to choose
Only the differences in our records. A value we couldn't verify never counts as a difference.
Choose ON Gold Standard Isolate if…
- You want more of each scoop to be protein (81% vs 78% by weight).
- You want less sugar (0 g vs 1 g per serving).
- You want a powder the brand labels gluten-free (our record for Dymatize ISO100 has no such label).
Choose Dymatize ISO100 if…
- You want more flavors to choose from (16 vs 2).
The two powders
Good to know
Labels and prices change, so check the package before buying, especially if you have allergies. If you are pregnant, nursing, buying for a child or managing a health condition, ask your doctor before adding a supplement.